The Yamassee War was a conflict fought in South Carolina from 1715–1717 between British settlers from the Province of Carolina and the Yamasee and a number of other allied Native American peoples, including the Muscogee, Cherokee, Catawba, Apalachee, Apalachicola, Yuchi, Savannah River Shawnee, Congaree, Waxhaw, Pee Dee, Cape Fear, Cheraw, and others. Some of the Native American groups played a minor role, while others launched attacks throughout South Carolina in an attempt to destroy the colony.
Native Americans killed hundreds of colonists and destroyed many settlements, and they killed traders throughout the southeastern region. Colonists abandoned the frontiers and fled to Charles Town, where starvation set in as supplies ran low. The survival of the South Carolina colony was in question during 1715. The tide turned in early 1716 when the Cherokee sided with the colonists against the Creek, their traditional enemy. The last Native American fighters withdrew from the conflict in 1717, bringing a fragile peace to the colony.